Factors associated with nonadherence to instructions for using the Nestorone®/ethinyl estradiol contraceptive vaginal ring.

ABSTRACT:

Objectives

We sought to identify factors associated with nonadherence to instructions for using a novel contraceptive providing 1 year of protection.

Study design

Data from a multicountry Phase 3 trial of the Nestorone® (segesterone acetate)/ethinyl estradiol (NES/EE) contraceptive vaginal ring (CVR) were analyzed. Participants were instructed to use the CVR over 13 cycles and follow a 21/7 regimen. Their reports of CVR removals >2 h outside scheduled removal periods served as a proxy for nonadherence. We used multivariate logistic regression to determine factors associated with such use.

Results

Of 905 participants, 120 (13%) reported CVR removals >2 h. Removals for washing [odds ratio (OR) 3.96, 95% confidence interval (CI) 2.50-6.27] or sexual intercourse (OR 3.19,

SUBMITTER: Stifani BM 

PROVIDER: S-EPMC5948138 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature