Airn Regulates Igf2bp2 Translation in Cardiomyocytes.

ABSTRACT:

Rationale

Increasing evidence indicates the presence of lncRNAs in various cell types. Airn is an imprinting gene transcribed from the paternal chromosome. It is in antisense orientation to the imprinted, but maternally derived, Igf2r gene, on which Airn exerts its regulation in cis. Although Airn is highly expressed in the heart, functions aside from imprinting remain unknown.

Objective

Here, we studied the functions of Airn in the heart, especially cardiomyocytes.

Methods and results

Silencing of Airn via siRNAs augmented cell death, vulnerability to cellular stress, and reduced cell migration. To find the cause of such phenotypes, the potential binding partners of Airn were identified via RNA pull-down followe

SUBMITTER: Hosen MR 

PROVIDER: S-EPMC5948151 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature