Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population.

ABSTRACT:

Background

The association between ABCC8 gene C49620T polymorphism and type 2 diabetes (T2D) in populations of diverse ethnic backgrounds has been reported. However, such occurrence in an African population is yet to be established. This case-control study involving 73 T2D and 75 non-diabetic (ND) patients investigated the occurrence of this polymorphism among T2D patients in Nigeria and assessed its relationship with body lipids of patients.

Methods

Demographic and clinical characteristics of patients were collected and lipid profile indices including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were assayed. Restriction fragment length polymorphism-PCR (RFLP-PCR) was employed to genotype the ABCC8-C49620T polym

SUBMITTER: Engwa GA 

PROVIDER: S-EPMC5948806 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature