Corynebacterium glutamicum as platform for the production of hydroxybenzoic acids.

ABSTRACT:

Background

Hydroxybenzoic acids are industrially relevant aromatic compounds, which also play key roles in the microbial carbon metabolism, e.g., as precursors for the synthesis of cofactors or metal-chelating molecules. Due to its pronounced resistance to aromatics Corynebacterium glutamicum represents an interesting platform for production of these compounds. Unfortunately, a complex catabolic network for aromatic molecules prevents application of C. glutamicum for microbial production of aromatic compounds other than aromatic amino acids, which cannot be metabolized by this microorganism.

Results

We completed the construction of the platform strain C. glutamicum DelAro⁵, in which the deletion of altogether 27 genes in five gene clusters abolished most of the pe

SUBMITTER: Kallscheuer N 

PROVIDER: S-EPMC5948850 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature