TIMP-2/IGFBP7 predicts acute kidney injury in out-of-hospital cardiac arrest survivors.

ABSTRACT: BACKGROUND:Acute kidney injury (AKI) is a common complication after cardiopulmonary resuscitation (CPR) and predicts in-hospital mortality. To which extent post-resuscitation disease or the initial event of cardiac arrest and the duration of insufficient cardiac output triggers AKI is challenging to discriminate. Knowledge on molecular mediators of AKI is scarce. Early identification of patients at high risk of AKI is hampered by the low sensitivity of the established tests in clinical routine practice. The present study aimed to determine the diagnostic utility of the novel urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) for the early recognition of AKI in patients with non-traumatic shock. METHODS:The performanc

SUBMITTER: Adler C 

PROVIDER: S-EPMC5948851 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature