Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart.

ABSTRACT:

Background

Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition remain poorly understood. We examined whether hypoxia-inducible factor 1 alpha, in combination with exposure to a diabetic intrauterine environment, influences the function and molecular structure of the adult offspring heart.

Methods and results

In a mouse model, we demonstrated that haploinsufficient (Hif1a^+/-) offspring from a diabetic pregnancy developed left ventricle dysfunction at 12 weeks of age, as manifested by decreased fractional shortening and structural remodeling of the myocardium. Transcriptional profiling by RNA-seq revealed significa

SUBMITTER: Cerychova R 

PROVIDER: S-EPMC5948854 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature