Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum.

ABSTRACT: Tonic inhibition in the brain is mediated through an activation of extrasynaptic GABA_A receptors by the tonically released GABA, resulting in a persistent GABAergic inhibitory action. It is one of the key regulators for neuronal excitability, exerting a powerful action on excitation/inhibition balance. We have previously reported that astrocytic GABA, synthesized by monoamine oxidase B (MAOB), mediates tonic inhibition via GABA-permeable bestrophin 1 (Best1) channel in the cerebellum. However, the role of astrocytic GABA in regulating neuronal excitability, synaptic transmission, and cerebellar brain function has remained elusive. Here, we report that a reduction of tonic GABA release by genetic removal or pharmacological inhibition of Best1 or MAOB caused an enhanced neuronal e

SUBMITTER: Woo J 

PROVIDER: S-EPMC5948981 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature