Differential expression patterns of housekeeping genes increase diagnostic and prognostic value in lung cancer.

ABSTRACT:

Background

Using DNA microarrays, we previously identified 451 genes expressed in 19 different human tissues. Although ubiquitously expressed, the variable expression patterns of these "housekeeping genes" (HKGs) could separate one normal human tissue type from another. Current focus on identifying "specific disease markers" is problematic as single gene expression in a given sample represents the specific cellular states of the sample at the time of collection. In this study, we examine the diagnostic and prognostic potential of the variable expressions of HKGs in lung cancers.

Methods

Microarray and RNA-seq data for normal lungs, lung adenocarcinomas (AD), squamous cell carcinomas of the lung (SQCLC), and small cell carcinomas of the lung (SCLC) were collected from online

SUBMITTER: Chang YC 

PROVIDER: S-EPMC5949062 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature