Synthesis, characterization, and interactions of single-walled carbon nanotubes modified with doxorubicin with Langmuir-Blodgett biomimetic membranes.

ABSTRACT: The synthesis, characterization, and the influence of single-walled carbon nanotubes (SWCNTs) modified with an anticancer drug doxorubicin (DOx) on the properties of model biological membrane as well as the comparison of the two modes of modification has been presented. The drug was covalently attached to the nanotubes either preferentially on the sides or at the ends of the nanotubes by the formation of hydrazone bond. The efficiency of the modification was proved by the results of FTIR, Raman, and thermogravimetric analysis. In order to characterize the influence of SWCNT-DOx conjugates on model biological membranes, Langmuir technique has been employed. The mixed monolayers composed of 1,2-dipalmitoyl-sn-glycero-3-phosphothioethanol (DPPTE) and SWCNT-DOx with different weight rat

SUBMITTER: Matyszewska D 

PROVIDER: S-EPMC5949139 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature