Influence of pathogen and focus of infection on procalcitonin values in sepsis patients with bacteremia or candidemia.

ABSTRACT:

Background

This study aimed to evaluate the accuracy of procalcitonin (PCT) serum concentrations to diagnose Gram-negative bacteremia and the association of PCT serum concentrations with more specific pathogens and the focus of infection.

Methods

Secondary analysis of the prospectively collected patient-level dataset from a cluster randomized quality improvement trial was performed. The trial included sepsis patients with organ dysfunction treated in the participating intensive care units from 2011 to 2015. Test performance for the prediction of Gram-negative bacteremia was assessed by receiver operating curve analysis. Independent effects of specific pathogen groups and foci of infection on PCT concentrations were assessed by linear logistic regression models.

Results

SUBMITTER: Thomas-Ruddel DO 

PROVIDER: S-EPMC5949148 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature