Mining the nucleus accumbens proteome for novel targets of alcohol self-administration in male C57BL/6J mice.

ABSTRACT:

Rationale

There is a clear need for discovery of effective medications to treat behavioral pathologies associated with alcohol addiction, such as chronic drinking.

Objective

The goal of this preclinical study was to assess effects of chronic alcohol drinking on the nucleus accumbens (NAcb) proteome to identify and validate novel targets for medications development.

Materials and methods

Two-dimensional difference in-gel electrophoresis (2D-DIGE) with matrix-assisted laser desorption ionization tandem time-of-flight (MALDI-TOF/TOF) was used to assess effects of chronic voluntary home-cage (24-h access) alcohol drinking on the NAcb proteome of C57BL/6J mice. To extend these findings to a model of alcohol self-administration and reinforcement, we investigated potential r

SUBMITTER: Faccidomo S 

PROVIDER: S-EPMC5949261 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature