Anticipatory prefrontal cortex activity underlies stress-induced changes in Pavlovian fear conditioning.

ABSTRACT: Excessive stress exposure often leads to emotional dysfunction, characterized by disruptions in healthy emotional learning, expression, and regulation processes. A prefrontal cortex (PFC)-amygdala circuit appears to underlie these important emotional processes. However, limited human neuroimaging research has investigated whether these brain regions underlie the altered emotional function that develops with stress. Therefore, the present study used functional magnetic resonance imaging (fMRI) to investigate stress-induced changes in PFC-amygdala function during Pavlovian fear conditioning. Participants completed a variant of the Montreal Imaging Stress Task (MIST) followed (25 min later) by a Pavlovian fear conditioning task during fMRI. Self-reported stress to the MIST was used to identif

SUBMITTER: Goodman AM 

PROVIDER: S-EPMC5949265 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature