Interleaved quantitative BOLD: Combining extravascular R₂' - and intravascular R₂-measurements for estimation of deoxygenated blood volume and hemoglobin oxygen saturation.

ABSTRACT: Quantitative BOLD (qBOLD), a non-invasive MRI method for assessment of hemodynamic and metabolic properties of the brain in the baseline state, provides spatial maps of deoxygenated blood volume fraction (DBV) and hemoglobin oxygen saturation (HbO₂) by means of an analytical model for the temporal evolution of free-induction-decay signals in the extravascular compartment. However, mutual coupling between DBV and HbO₂ in the signal model results in considerable estimation uncertainty precluding achievement of a unique set of solutions. To address this problem, we developed an interleaved qBOLD method (iqBOLD) that combines extravascular R₂' and intravascular R₂ mapping techniques so as to obtain prior knowledge for the two unknown parameters. To a

SUBMITTER: Lee H 

PROVIDER: S-EPMC5949279 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature