INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division.

ABSTRACT: Adaptive survival requires the coordination of nutrient availability with expenditure of cellular resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes synchronize and exhibit periodic bursts of expression in coordination with respiration and cell division in the yeast metabolic cycle (YMC). Despite the importance of metabolic and proliferative synchrony, the majority of YMC regulators are currently unknown. Here, we demonstrate that the INO80 chromatin-remodeling complex is required to coordinate respiration and cell division with periodic gene expression. Specifically, INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. In mutant cells, chromatin accessibility of periodic

SUBMITTER: Gowans GJ 

PROVIDER: S-EPMC5949282 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature