Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population.

ABSTRACT:

Purpose

Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers.

Materials and methods

An SNP analysis was performed by whole exon sequencing of the EBF2 gene. Our study comprised a total of 495 subjects (295 KD patients and 200 unrelated normal controls) from a Korean population. Tag SNPs were discovered using the Haploview program. Genotyping of the EBF2 gene was performed with the TaqMan® assay with real-time PCR methods.

Results

Polymorphism

SUBMITTER: Bae Y 

PROVIDER: S-EPMC5949294 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature