Rejection Prophylaxis in Corneal Transplant.

ABSTRACT: BACKGROUND:Graft rejection. Twenty to thirty percent of patients with corneal transplants experience at least one rejection episode in the first 5 years after transplantation. Prophylaxis through matching for human leukocyte antigens (HLA) is controversial. We herein report the results of the Functional ANtigen matChing in keratoplastY (FANCY) trial. METHODS:FANCY was a randomized, double-blind, multicenter clinical trial. The primary objective was to evaluate superiority of HLA matching versus random graft assignment. The primary endpoint was rejection-free graft survival. We included both normal-risk and high-risk indications. The study is registered with ClinicalTrials. gov (NCT00810472). RESULTS:721 patients were included, 639 patients were randomized. 474 patients underwent keratoplas

SUBMITTER: Bohringer D 

PROVIDER: S-EPMC5949374 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature