Lung cancer early detection and health disparities: the intersection of epigenetics and ethnicity.

ABSTRACT: Lung cancer is the most prominent cause of cancer-related mortality. Significant disparities in incidence and outcome characterize the disease's manifestations among ethnically and racially diverse populations. Complete surgical resection is the most effective curative treatment. However, success relies on early tumor detection. The National Lung Cancer Screening trial showed that lung cancer related mortality can be reduced by the use of low-dose CT (LDCT) screening. However, this test is plagued by a high false positive rate of 97% and the device itself is limited to designated cancer centers due to its expense and size. This restriction makes it difficult for underserved groups to access LDCT screening, the current standard of care. Highly sensitive and specific epigenetic DNA methylati

SUBMITTER: Lerner L 

PROVIDER: S-EPMC5949470 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature