Platelets Promote Brucella abortus Monocyte Invasion by Establishing Complexes With Monocytes.

ABSTRACT: Brucellosis is an infectious disease elicited by bacteria of the genus Brucella. Platelets have been extensively described as mediators of hemostasis and responsible for maintaining vascular integrity. Nevertheless, they have been recently involved in the modulation of innate and adaptive immune responses. Although many interactions have been described between Brucella abortus and monocytes/macrophages, the role of platelets during monocyte/macrophage infection by these bacteria remained unknown. The aim of this study was to investigate the role of platelets in the immune response against B. abortus. We first focused on the possible interactions between B. abortus and platelets. Bacteria were able to directly interact with platelets. Moreover, this interaction triggered platelet activation

SUBMITTER: Trotta A 

PROVIDER: S-EPMC5949576 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature