Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.

ABSTRACT:

Background

Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose-response relationship of telmisartan, an antihypertensive, on adipocytes in vitro in order to determine whether it may have metabolic beneficial effects.

Methods

Using in vitro chronic toxicity models (3T3-F442A murine and primary human adipocytes), we evaluated the effects of different concentrations of telmisartan on adipocyte differentiation and adipogenic gene expression using lipid accumulation assays and real-time polymerase chain reaction, respectively. Adipokine secretion and expression of insulin signalling mediators were eval

SUBMITTER: Pushpakom SP 

PROVIDER: S-EPMC5949706 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature