Probing the surface-localized hyperthermia of gold nanoparticles in a microwave field using polymeric thermometers.

ABSTRACT: The surface-localized hyperthermia of gold nanoparticles under microwave irradiation was examined. Gold nanoparticles with a hydrodynamic diameter of ∼6 nm stabilized by polymeric "thermometers" were used to gather information on the extent of heating as well as its spatial confinements. Reversible addition-fragmentation chain transfer polymerization was employed to synthesize well-defined, functional polymers of predetermined molecular weights, allowing for estimation of the distance between the nanoparticle surface and the polymer chain end. The polymers were conjugated with a fluorescent dye separated by a thermally-labile azo linkage, and these polymeric ligands were bound to gold nanoparticles via gold-thiolate bonds. Conventional heating experiments elucidated the relationship

SUBMITTER: Kabb CP 

PROVIDER: S-EPMC5949850 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature