Pd(ii)-catalyzed remote regiodivergent ortho- and meta-C-H functionalizations of phenylethylamines.

ABSTRACT: Site selectivity control is of vital importance in the direct functionalization of inert C-H bonds. Reported here is a novel example of remote regiodivergent ortho- and meta-C-H bond functionalizations of phenylethylamine derivatives by using a novel 2-cyanobenzoyl group as the original directing functionality, where the regioselectivity was adjusted by a methylation. The potential of the method was exemplified by sequential functionalizations of both ortho- and meta-C-H bonds of a phenylethylamine derivative in a streamlined manner.

SUBMITTER: Li S 

PROVIDER: S-EPMC5949857 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature