Benzodiazepines and risk for hepatic encephalopathy in patients with cirrhosis and ascites.

ABSTRACT:

Background

There is limited evidence to support the belief that benzodiazepines increase cirrhosis patients' risk of hepatic encephalopathy (HE).

Objective

We aimed to examine the association between benzodiazepine use and HE development in cirrhosis patients.

Methods

We used data on 865 cirrhosis patients with ascites from three trials to study the effect of benzodiazepine use on development of first-time HE. For each patient, we classified periods of benzodiazepine use by the number of days since initiation. We used Cox regression to compare the risk of HE in current benzodiazepine users vs. non-users adjusting for confounders.

Results

Cirrhosis patients were not at increased risk of HE for the first two days of benzodiazepine use, but then faced a five-fold

SUBMITTER: Gronbæk L 

PROVIDER: S-EPMC5949964 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature