Genetic variations in the TLR3 locus are associated with eosinophilic esophagitis.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is an antigen-driven disease mediated by an abnormal immune Th2 response.

Objective

The objective of this article is to investigate genes associated with regulating immune responses leading to disease susceptibility.

Methods

Twenty-seven tag single nucleotide polymorphisms (tSNPs) selected in five candidate genes (TLR3, TLR4, FOXP3, FLG and TSLP) were genotyped in 218 EoE patients and 376 controls. Skin prick tests were carried out in EoE patients with a panel of 17 aeroallergens and 22 plant- and animal-derived foods.

Results

Five tSNPs located in the TSLP locus and one tSNP located in the TLR3 locus were significantly associated with EoE. The interactions between TLR3 and TSLP

SUBMITTER: Avila-Castellano R 

PROVIDER: S-EPMC5949969 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature