Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor.

ABSTRACT: The general stress response sigma factor σ^E1 directly and indirectly regulates the transcription of dozens of genes that influence stress survival and host infection in the zoonotic pathogen Brucella abortus Characterizing the functions of σ^E1-regulated genes therefore would contribute to our understanding of B. abortus physiology and infection biology. σ^E1 indirectly activates transcription of the IclR family regulator Bab2_0215, but the function of this regulator remains undefined. Here, we present a structural and functional characterization of Bab2_0215, which we have named B rucella adipic acid-activated regulator (BaaR). We found that BaaR adopts a classic IclR-family fold and directly represses the tra

SUBMITTER: Herrou J 

PROVIDER: S-EPMC5949995 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature