Copper-catalyzed diastereoselective aerobic intramolecular dehydrogenative coupling of hydrazones via sp³ C-H functionalization.

ABSTRACT: Transition metal-catalyzed cross dehydrogenative coupling is an important tool for functionalization of the α Csp³-H bond of amines. Among this reaction category, copper-catalyzed selective C-C bond formation under atmospheric O₂ is of considerable research interest and significant progress has been achieved in recent years. In comparison, development of the intramolecular version of this transformation is still in its infancy. Furthermore, diastereoselective cyclization with this transformation has not been achieved. Here, we describe the highly diastereoselective intramolecular dehydrogenative cyclization of N,N-disubstituted hydrazones by a copper-catalyzed sp³ C-H bond functionalization process. The reaction protocol utilizes O₂

SUBMITTER: Wu X 

PROVIDER: S-EPMC5950562 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature