Quantifying the burden of steroid-related damage in SLE in the Hopkins Lupus Cohort.

ABSTRACT:

Objective

Corticosteroids are a mainstay of SLE treatment; however, cumulative steroid exposure may lead to organ damage. This study aimed to quantify the risk of new diabetes, hypertension, cataracts, osteoporosis and avascular necrosis that is attributable to cumulative corticosteroid exposure in SLE.

Methods

Using data from the Hopkins Lupus Cohort, a longitudinal study of lupus activity, organ damage and quality of life in patients with SLE, five matched case-control analyses nested within a prospectively enrolled SLE cohort were performed. Two randomly selected controls were matched to each case using incidence-density sampling from defined risk sets. Attributable risk was calculated for steroid exposure (dose and duration, separately). Cumulative steroid dose was model

SUBMITTER: Davidson JE 

PROVIDER: S-EPMC5950698 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature