Injuries to the Immature Optic Radiation Show Correlated Thinning of the Macular Ganglion Cell Layer.

ABSTRACT: Injuries to the immature optic radiation (OR) are associated with thinning of the retinal nerve fiber layer and corresponding visual field (VF) defects. The aim of the current study was to seek evidence for causal retrograde trans-synaptic degeneration by exploring the correspondence between the localization and extension of the injury to the OR and the structure of the macular ganglion cell complex, and the relation to VF function. Seven adults (age range 18-35) with visual dysfunction secondary to white-matter damage of immaturity and six healthy adults (age range 22-33) underwent magnetic resonance imaging (MRI). Fiber tractography was used to generate the geniculate projections to the dorsal and ventral striate cortex, delineated by retinotopic functional MRI mapping. The structure of

SUBMITTER: Lennartsson F 

PROVIDER: S-EPMC5950728 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature