Oxatub[4]arene: a smart macrocyclic receptor with multiple interconvertible cavities.

ABSTRACT: There are a large number of synthetic macrocyclic receptors in the literature. No particular one is suitable for all guests or purposes. For a broader guest binding scope or multiple purposes, a macrocycle with multiple interconvertible cavities will be advantageous. Here, we report a naphthalene-based macrocyclic receptor with an adaptable cavity, namely oxatub[4]arene. It has four representative conformations resulting from the flipping of naphthalene rings, each with a deep and well-defined cavity. Different guests select one host conformer or a combination of conformers. All the four conformers have been detected and characterized based on 2D NMR spectra and X-ray single crystal structures. Thermodynamically, these conformers constitute a reservoir, that responds to the structural chan

SUBMITTER: Jia F 

PROVIDER: S-EPMC5950800 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature