Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.

ABSTRACT:

Aims

Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH.

Methods and results

We pooled individual patient-data (n = 2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22 German centres) and eventually identified MHV-patients (n = 137) with anticoagulation-associated ICH for outcome analyses. The primary outcome consisted of major haemorrhagic complications analysed during hos

SUBMITTER: Kuramatsu JB 

PROVIDER: S-EPMC5950928 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature