Pharmacokinetic and Pharmacodynamic Variability of Insulin When Administered by Jet Injection.

ABSTRACT:

Background

Jet injection has been shown to accelerate the absorption and action of rapid-acting insulin. In this study, we compared the variability of absorption characteristics between jet injection and conventional administration of the rapid-acting insulin analogue aspart.

Methods

A total of 30 healthy volunteers were enrolled in this randomized controlled blinded parallel study. On two test days, they received insulin aspart (0.2 units/kg body weight), either by jet injection or conventional pen, followed by a 6-hour euglycemic glucose clamp. Plasma glucose and insulin levels and glucose infusion rates were measured every 5 to 10 minutes to calculate the variability in pharmacological endpoints.

Results

Jet injection advanced the times until maximal insulin concen

SUBMITTER: Engwerda EEC 

PROVIDER: S-EPMC5950987 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature