Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy.

ABSTRACT: Cerebral autoregulation (CA) maintains cerebral blood flow (CBF) in the presence of systemic blood pressure changes. Brain injury can cause loss of CA and resulting dysregulation of CBF, and the degree of CA impairment is a functional indicator of cerebral tissue health. Here, we demonstrate a new approach to noninvasively estimate cerebral autoregulation in healthy adult volunteers. The approach employs pulsatile CBF measurements obtained using high-speed diffuse correlation spectroscopy (DCS). Rapid thigh-cuff deflation initiates a chain of responses that permits estimation of rates of dynamic autoregulation in the cerebral microvasculature. The regulation rate estimated with DCS in the microvasculature (median: 0.26 s-1, inter quartile range: 0.19 s-1) agrees well (R = 0.81, slope = 0.9

SUBMITTER: Parthasarathy AB 

PROVIDER: S-EPMC5951022 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature