FMRI brain activation changes following treatment of a first bipolar manic episode.

ABSTRACT:

Objectives

We tested the hypothesis that, with treatment, functional magnetic resonance imaging (fMRI) regional brain activation in first-episode mania would normalize - i.e., that differences from healthy subjects would diminish over time, and would be associated with clinical remission status, potentially identifying neuroanatomic treatment response markers.

Methods

Forty-two participants with bipolar I disorder were recruited during their first manic episode, pseudo-randomized to open-label lithium or quetiapine, and followed for 8 weeks. fMRI scans were obtained at baseline and then after 1 and 8 weeks of treatment, while participants performed a continuous performance task with emotional distracters. Healthy participants received fMRI scans at these same intervals. Spec

SUBMITTER: Strakowski SM 

PROVIDER: S-EPMC5951160 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature