The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers.

ABSTRACT: The rise in genomic knowledge over the past decade has revealed the molecular etiology of many diseases, and has identified intricate signaling network activity in human cancers. Genomics provides the opportunity to determine genome structure and capture the activity of thousands of molecular events concurrently, which is important for deciphering highly complex genetic diseases such as cancer. In this review, we focus on genomic efforts directed towards one of cancer's most frequently mutated networks, the RAS pathway. Genomic tools such as gene expression signatures and assessment of mutations across the RAS network enable the capture of RAS signaling complexity. Due to this high level of interaction and cross-talk within the network, efforts to target RAS signaling in the clinic have ge

SUBMITTER: Shrestha G 

PROVIDER: S-EPMC5951171 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature