Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents.

ABSTRACT:

Objective

This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing. A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later.

Method

Functional imaging responses to three paradigms-the stop-signal, monetary incentive delay, and faces tasks-were collected in youths at age 14, as part of the IMAGEN study. At baseline, youths from London and Dublin sites were assessed on psychotic-like experiences, and those reporting significant experiences were compared with matched control subjects. Significant brain activity differences between the groups were used to predict, with cross-validation, the pr

SUBMITTER: Bourque J 

PROVIDER: S-EPMC5951182 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature