B-Type Natriuretic Peptide Levels and Mortality in Patients With and Without Heart Failure.

ABSTRACT: BACKGROUND:Circulating B-type natriuretic peptide (BNP) concentrations strongly predict mortality in patients with heart failure (HF). Both cardiac and extracardiac stimuli influence BNP levels, suggesting that BNP might have similar prognostic value in patients without HF. OBJECTIVES:The aim of this study was to compare the prognostic value of BNP between patients with and those without HF. METHODS:Using the Vanderbilt University Medical Center electronic health record, 30,487 patients (median age 63 years, 50% men, 17% black, 38% with HF) who had a first plasma BNP measurement between 2002 and 2013, with follow-up through 2015, were studied. The risk for death according to BNP level was quantified using multivariate Cox proportional hazards models. RESULTS:BNP levels were lower in patien

SUBMITTER: York MK 

PROVIDER: S-EPMC5951190 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature