The first chiral diene-based metal-organic frameworks for highly enantioselective carbon-carbon bond formation reactions.

ABSTRACT: We have designed the first chiral diene-based metal-organic framework (MOF), E₂-MOF, and postsynthetically metalated E₂-MOF with Rh(i) complexes to afford highly active and enantioselective single-site solid catalysts for C-C bond formation reactions. Treatment of E₂-MOF with [RhCl(C₂H₄)₂]₂ led to a highly enantioselective catalyst for 1,4-additions of arylboronic acids to α,β-unsaturated ketones, whereas treatment of E₂-MOF with Rh(acac)(C₂H₄)₂ afforded a highly efficient catalyst for the asymmetric 1,2-additions of arylboronic acids to aldimines. Interestingly, E₂-MOF·Rh(acac) showed higher activity and enantioselectivity than the homogeneous control catalys

SUBMITTER: Sawano T 

PROVIDER: S-EPMC5951194 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature