Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration.

ABSTRACT: Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated fibroblasts can acquire an activated phenotype and produce excessive amounts of extracellular matrix creating a highly dense stroma, a situation known as desmoplasia. Desmoplasia, along with the uncontrolled proliferation of cancer cells, leads to the development of compressive forces within the tumor, generating the so-called solid stress. Solid stress is previously shown to affect cancer cell proliferation and migration, however there is no pertinent study taking into account the effects of solid stress on fibroblasts and whether these effects contribute to tumor progressio

SUBMITTER: Kalli M 

PROVIDER: S-EPMC5951267 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature