Extended surface for membrane association in Zika virus NS1 structure.

ABSTRACT: The Zika virus, which has been implicated in an increase in neonatal microcephaly and Guillain-Barré syndrome, has spread rapidly through tropical regions of the world. The virulence protein NS1 functions in genome replication and host immune-system modulation. Here, we report the crystal structure of full-length Zika virus NS1, revealing an elongated hydrophobic surface for membrane association and a polar surface that varies substantially among flaviviruses.

SUBMITTER: Brown WC 

PROVIDER: S-EPMC5951387 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature