Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra.

ABSTRACT: Peptidic natural products (PNPs) include many antibiotics and other bioactive compounds. While the recent launch of the Global Natural Products Social (GNPS) molecular networking infrastructure is transforming PNP discovery into a high-throughput technology, PNP identification algorithms are needed to realize the potential of the GNPS project. GNPS relies on the assumption that each connected component of a molecular network (representing related metabolites) illuminates the 'dark matter of metabolomics' as long as it contains a known metabolite present in a database. We reveal a surprising diversity of PNPs produced by related bacteria and show that, contrary to the 'comparative metabolomics' assumption, two related bacteria are unlikely to produce identical PNPs (even though they are lik

SUBMITTER: Gurevich A 

PROVIDER: S-EPMC5951390 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature