User evaluations offer promise for pod-intravaginal ring as a drug delivery platform: A mixed methods study of acceptability and use experiences.

ABSTRACT:

Background

Effective HIV prevention requires efficient delivery of safe and efficacious drugs and optimization of user adherence. The user's experiences with the drug, delivery system, and use parameters are critical to product acceptability and adherence. Prevention product developers have the opportunity to directly control a drug delivery system and its impact on acceptability and adherence, as well as product efficacy. Involvement of potential users during preclinical design and development can facilitate this process. We embedded a mixed methods user evaluation study into a safety and pharmacokinetics (PK) trial of a pod-intravaginal ring delivering antiretroviral agents.

Methodology

Women enrolled in two cohorts, ultimately evaluating the safety/PK of a pod-IVRs delive

SUBMITTER: Guthrie KM 

PROVIDER: S-EPMC5951541 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature