Acute effects of insulin on circulating natriuretic peptide levels in humans.

ABSTRACT:

Background

The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides. It has been proposed that insulin influences natriuretic peptide production.

Objective

We sought to determine the acute effects of insulin administration on natriuretic peptide concentrations.

Methods

31 men and women (11 lean, 10 overweight, and 10 obese), ages 30-70 years, without cardiovascular disease or overt diabetes underwent a hyperinsulinemic-euglycemic insulin clamp. Plasma concentrations of N-terminal pro atrial natriuretic peptide (NT-proANP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured

SUBMITTER: Bachmann KN 

PROVIDER: S-EPMC5951576 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature