Gold(I)-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals.

ABSTRACT: Au(I) in combination with AgOTf enables the unprecedented direct and α-stereoselective catalytic synthesis of deoxyglycosides from glycals. Mechanistic investigations suggest that the reaction proceeds via Au(I)-catalyzed hydrofunctionalization of the enol ether glycoside. The room temperature reaction is high yielding and amenable to a wide range of glycal donors and OH nucleophiles.

SUBMITTER: Palo-Nieto C 

PROVIDER: S-EPMC5951607 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature