Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval.

ABSTRACT:

Background

Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low-frequency variants also contribute to PR interval heritability.

Methods

We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African ancestry. We examined both common and rare variants associated with the PR interval.

Results

We identified 31 genetic loci that were significantly associated with PR interval after Bonferroni correction (P<1.2×10^-6), including 11 novel loci that have not been repo

SUBMITTER: Lin H 

PROVIDER: S-EPMC5951629 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature