Infections and the relationship to treatment in neuromuscular autoimmunity.

ABSTRACT:

Introduction

This study aimed to identify infections in patients with myasthenia gravis, dermatomyositis, and chronic inflammatory demyelinating polyradiculoneuropathy, and to investigate the relationship between infection and immunomodulation.

Methods

A retrospective chart review examined 631 patients with myasthenia gravis (n = 358), chronic inflammatory demyelinating polyradiculoneuropathy (n = 124), and dermatomyositis (n = 149) patients over a 10-year time period.

Results

Infection rates were similar at approximately 19% in all 3 diseases. Of the infections in which a causative organism was identified, pneumonia, sepsis, and opportunistic infections were the leading diagnoses. A multivariate model demonstrated a significant association between infection and an in

SUBMITTER: Prior DE 

PROVIDER: S-EPMC5951723 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature