Methodology for controlled administration of smoked synthetic cannabinoids JWH-018 and JWH-073.

ABSTRACT: Synthetic cannabinoids (SCs) are a significant public health concern given their widespread use and severe effects associated with intoxication. However, there is a paucity of controlled human studies investigating the behavioral and physiological effects and pharmacokinetics of these compounds. Designing a reliable method to administer consistent, concentration-dependent synthetic cannabinoids is an integral component of controlled study of these compounds. Further, optimizing methods to assess the parent compounds and metabolites in plasma is critical in order to be able to establish their pharmacokinetics after administration. To develop a reliable method to administer smokable, concentration-dependent SCs, cigarettes were prepared with plant matter adulterated with increasing concentra

SUBMITTER: Cooper ZD 

PROVIDER: S-EPMC5951724 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature