Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy.

ABSTRACT:

Introduction

Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. This study evaluates the use of proton magnetic resonance spectroscopy (¹ H MRS) as a biomarker of muscle strength and function in FSHD.

Methods

Thirty-six individuals with FSHD and 15 healthy controls underwent multivoxel ¹ H MRS of a cross-section of the mid-thigh. Concentrations of creatine, intramyocellular and extramyocellular lipids, and trimethylamine (TMA)-containing compounds in skeletal muscle were calculated. Metabolite concentrations for individuals with FSHD were compared with those of controls. The relationship between metabolite concentrations and muscle strength was also examined.

Results

The TMA/creatine (Cr

SUBMITTER: Leung DG 

PROVIDER: S-EPMC5951728 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature