Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats.

ABSTRACT: Implicit learning about antecedent stimuli and the unconditional stimulus (US) properties of alcohol may facilitate the progressive loss of control over drinking. To model this learning, Cofresí et al. (2017) developed a procedure in which a discrete, visual conditional stimulus (houselight illumination; CS) predicted the availability of a retractable sipper that rats could lick to receive unsweetened alcohol [Alcoholism: Clinical and Experimental Research, 41, 608-617]. Here we investigated the possibility that houselight illumination, sipper presentation, and oral alcohol receipt might each exert control over alcohol seeking and drinking. We also determined the relationship between ingested dose and blood alcohol concentration, in order to validate the idea that the US is a post-ingestiv

SUBMITTER: Cofresi RU 

PROVIDER: S-EPMC5951740 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature