Anatomy-guided joint tissue segmentation and topological correction for 6-month infant brain MRI with risk of autism.

ABSTRACT: Tissue segmentation of infant brain MRIs with risk of autism is critically important for characterizing early brain development and identifying biomarkers. However, it is challenging due to low tissue contrast caused by inherent ongoing myelination and maturation. In particular, at around 6 months of age, the voxel intensities in both gray matter and white matter are within similar ranges, thus leading to the lowest image contrast in the first postnatal year. Previous studies typically employed intensity images and tentatively estimated tissue probabilities to train a sequence of classifiers for tissue segmentation. However, the important prior knowledge of brain anatomy is largely ignored during the segmentation. Consequently, the segmentation accuracy is still limited and topological err

SUBMITTER: Wang L 

PROVIDER: S-EPMC5951769 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature