Aberrant Effective Connectivity of the Right Anterior Insula in Primary Insomnia.

ABSTRACT:

Objective

Daytime cognitive impairment is an essential symptom of primary insomnia (PI). However, the underlying neural substrate remains largely unknown. Many studies have shown that the right anterior insula (rAI) as a key node of salience network (SN) plays a critical role in switching between the executive control network (ECN) and the default mode network (DMN) for better performance of cognitively demanding tasks. Aberrant effective connectivity (directional functional connectivity) of rAI with ECN or DMN may be one reason for daytime cognitive impairment in PI patients. Up to now, no effective connectivity study has been conducted on patients with PI during resting state. Our aim is to investigate the effective connectivity between the rAI and the other voxels in the whole b

SUBMITTER: Li C 

PROVIDER: S-EPMC5951943 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature