Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites.

ABSTRACT: BACKGROUND:Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites. OBJECTIVE:We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with MetS with ranging levels of insulin resistance. RESEARCH DESIGN AND METHODS:In this cross-sectional study, we evaluated L, K and delta cell density in duodenal biopsies from treatment-naïve males with MetS using machine-learning methodology. RESULTS:We identified specific clinical biomarkers and plasma metabolites associated with L cell and delta cell density. L cell density was associated with increased plasma metabolite levels incl

SUBMITTER: van Baar ACG 

PROVIDER: S-EPMC5952241 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature